HCID 3061990, compound → HCID 19819802, compound

HRID 1031146Notes

Reaction equation

HRID 1031146 reaction equation
[CH3:1][NH:2][CH:3]([C:11]1[S:12][CH:13]=[CH:14][C:15]=1[CH3:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH2:17](NC(C1SC=CC=1)CC1C=CC=CC=1)C>>[CH2:1]([NH:2][CH:3]([C:11]1[S:12][CH:13]=[CH:14][C:15]=1[CH3:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:17].[CH3:16][C:15]1[CH:14]=[CH:13][S:12][C:11]=1[CH:3]([NH2:2])[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 3061990HCID 3061990, compoundHCID 19819821N,3-Dimethyl-α-(phenylmethyl)-2-thiophenemethanamine

Product 2

HCID 19819802HCID 19819802, compoundHCID 19819810HCID 19819810, compound

Procedure

By following essentially the same procedure as described for Example 2 but substituting; N-methyl-α-(3-methyl-2-thienyl)benzeneethanamine; N-ethyl-α-(2-thienyl)benzeneethanamine; or N-ethyl-α-(3-methyl-2-thienyl)benzeneethanamine for the α-(3-methyl-2-thienyl)benzeneethanamine results in the preparation of; N-methyl-N-[l-(3-methyl-2-thienyl)-2-phenylethyl]-2-aminoacetamide (Z)-2-butenedioate (1:2) salt (mp 128°-130° C.); N-ethyl-N-[l-(2-thienyl)-2-phenylethyl]-2-aminoacetamide (Z)-2-butenedioate (1:1) salt (mp 134°-138° C.); or N-ethyl-N-[1-(3-methyl-2-thienyl)-2-phenylethyl]-2-aminoacetamide (Z)-2-butenedioate (1:1.5) salt (mp 110°-112° C.).

Sources & evidence

ORD record
ord-2a2940a2e31646299657396a6561989f
Source dataset
uspto-grants-1992_04
Patent number
US05109017

Reaction notes

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