Potassium Hydroxide → 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)-methyl]-2H-1,2,3-triazole

Participants

Role	Name	HCID	Charge
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	1H-Imidazole-4,5-dicarbonitrile, 2-amino-	HCID 170446	—
Reactant	Sodium cyanoborohydride	HCID 5003444	—
Reactant	2-(2,6-Dichloro-4-trifluoromethylphenyl)-1,2,3-triazole-4-carboxaldehyde	HCID 19778308	—
Solvent	Methanol	HCID 887	—
Product	2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)-methyl]-2H-1,2,3-triazole	HCID 19778373	—

Reaction Steps

Sodium cyanoborohydride (0.05 g) was added to a solution of 2-(2,6-dichloro-4-trifluoromethylphenyl)-1,2,3-triazole-4-carboxaldehyde (0.3 g), potassium hydroxide (0.04 g) and 2-amino-4,5-dicyanoimidazole (0.3 g) in methanol (20 ml). After 20 hours at room temperature, the solvent was evaporated under reduced pressure and the residue purified by silica gel chromatography to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-[(4,5-dicyano-1H-imidazol-2-ylamino)-methyl]-2H-1,2,3-triazole, m.p. 213°-215°. (Compound 25)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05109012
Source dataset	uspto-grants-1992_04
ORD ID	ord-3bd80c9a343f45a7afd65a723c0c6022
Source note	uspto-grants-1992_04