Triethylamine → HCID 131717317, compound

Participants

Reaction Steps

To 50 mL of toluene was added 5.0 g (0.0171 mol) of 2-(2-chloroethyl)-3,4-dihydro-1,4-dimethyl-1H-[1,3,5]triazepino[3,2-a]benzimidazol-5(2H)-one, 5.58 g (0.034 mol) of 2-(2-pyridyl)piperazine, and 3.4 g (0.034 mol) of triethylamine, and the entire reaction mixture heated to reflux. After 2 days, 1.5 g (0.009 mol) of 1-(2-pyridinyl)piperazine was added and reflux continued for 24 hours. The reaction mixture was washed with 2×50 mL of 1N NaOH, dried over Na2SO4, filtered and concentrated by rotary evaporation. The residue was subjected to preparative HPLC using silica gel as the stationary phase and eluting with 5% triethylamine in acetone. Like fraction were combined affording ~4.0 g (55%) of a glass.

Provenance & Evidence