HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → Benzhydryl 7beta-tert-butoxycarbonylamino-3-(3-formamido-2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | 5-Formamido-1-methylpyrazole | HCID 2755869 | — |
| Edukt | (6R,7R)-Benzhydryl 7-((tert-butoxycarbonyl)amino)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 11756232 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | Benzhydryl 7beta-tert-butoxycarbonylamino-3-(3-formamido-2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide | HCID 10628738 | 98,3% |
Reaktionsschritte
To a mixture of benzhydryl 7β-tert-butoxycarbonylamino-3-chloromethyl-3-cephem-4-carboxylate (15 g) and sodium iodide (4.37 g) in acetone (15 ml) was added 5-formamido-1-methylpyrazole (15 g) at ambient temperature. After being stirred for 40 hours at the same temperature, the mixture was poured into a mixture of water and ethyl acetate. The organic layer was separated and washed with water, aqueous sodium chloride solution, and dried over magnesium sulfate. The solution was evaporated in vacuo to give benzhydryl 7β-tert-butoxycarbonylamino-3-(3-formamido-2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (20.95 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05108997 |
| Quelldatensatz | uspto-grants-1992_04 |
| ORD ID | ord-4caf531abebe4a639379e44aa40b273a |
| Quellennotiz | uspto-grants-1992_04 |