Hydrochloric Acid → HCID 131717327, compound

Participants

Reaction Steps

A suspension of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate (syn-isomer) (10 g) in water (10 ml) is adjusted to pH 1.0 with 2N-hydrochloric acid at 20° C. with stirring. The resulting solution is further stirred at the same temperature for 2 hours and the resultant crystals are collected by filtration and dried to give crystals of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate hydrochloride (syn-isomer) (6.7 g).

Provenance & Evidence