Isobutylene → HCID 86744052, compound

Participants

Reaction Steps

A suspension of 4-methylaminocarbonyl-2-(2-methylpropyl)but-2-enoic acid (2.4 g) in chloroform (35 ml) was treated with an excess of isobutylene (30 ml) and concentrated sulphuric acid (3 drops) was added as catalyst. The mixture was stirred at room temperature in a sealed vessel for 8 days. The product was purified by silica gel chromatography [chloroformpentane (1:1) as eluant] to give the title compound (2.5 g, 81%), m.p. 35°-36° C. (pentane).

Provenance & Evidence