Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1031283Generated: October 25, 2026

4-Toluenesulfonyl chloride → p-Toluenesulfonamide, N-benzyl-

https://huagongshe.com/reaction/1031283

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
ReactantBenzylamineHCID 7504—
ReagentSodium BicarbonateHCID 516892—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
SolventPentaethylene glycolHCID 62551—
Productp-Toluenesulfonamide, N-benzyl-HCID 95801100%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/co400012m
Source dataset39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
ORD IDord-d2c4ec0927a44a2b8b90f7ace120ecf4
Source note39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"