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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1031287Generated: October 29, 2026

4-Toluenesulfonyl chloride → N-cyclopropyl-4-methylbenzenesulfonamide

https://huagongshe.com/reaction/1031287

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
ReactantCyclopropylamineHCID 69828—
ReagentSodium BicarbonateHCID 516892—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
SolventPentaethylene glycolHCID 62551—
ProductN-cyclopropyl-4-methylbenzenesulfonamideHCID 419009598%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/co400012m
Source dataset39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
ORD IDord-fad05a16500b48ffba64bb9c56303c57
Source note39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"