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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1031288Generated: October 30, 2026

4-Toluenesulfonyl chloride → N,4-Dimethyl-N-phenylbenzenesulfonamide

https://huagongshe.com/reaction/1031288

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
ReactantN-MethylanilineHCID 7515—
ReagentSodium BicarbonateHCID 516892—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
SolventPentaethylene glycolHCID 62551—
ProductN,4-Dimethyl-N-phenylbenzenesulfonamideHCID 22002395%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/co400012m
Source dataset39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
ORD IDord-e9be4dfdfbf445aaaec5e20a86047cb9
Source note39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"