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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1031289Generated: October 29, 2026

4-Toluenesulfonyl chloride → 4-((4-Methylphenyl)sulphonyl)morpholine

https://huagongshe.com/reaction/1031289

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Toluenesulfonyl chlorideHCID 7397—
ReactantMorpholineHCID 8083—
ReagentSodium BicarbonateHCID 516892—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
SolventPentaethylene glycolHCID 62551—
Product4-((4-Methylphenyl)sulphonyl)morpholineHCID 80645100%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1021/co400012m
Source dataset39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
ORD IDord-fae8732b1f0f4d6a831af0156c37bd51
Source note39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"