反应详情

温度

85 °C

Concentrated H2SO4 (35 g) was added to 10 ml of 90% HNO3 and at 75°-85° C., 13 g (0.1 mol) of 5-chloro-1,3-dimethylpyrazole was added dropwise with stirring to maintain the temperature at 85° C. After completion of the addition, the mixture was heated at 75 -85° C. for 1.5 hr. The nitration mixture was cooled and poured into ice. The suspension was filtered and the solid was washed with water and dried to give 14.5 g of the title compound. m.p. 70° C.

1. additionAfter completion of the addition
2. temperaturethe mixture was heated at 75 -85° C. for 1.5 hr
3. temperatureThe nitration mixture was cooled
4. additionpoured into ice
5. filtrationThe suspension was filtered
6. washthe solid was washed with water
7. customdried