反应详情

Sodium borohydride (6.62 g) was added in portions to propionic acid (52.5 ml), cooled to 5°, maintaining the temperature below 20°. N-methyloctylamine (5 g) was added dropwise, keeping the temperature at 20°. The reaction was stirred at 80° for 3 hours, cooled and basified with 2N sodium hydroxide. The aqueous solution was extracted with dichloromethane (2×75 ml). The combined extracts were dried with anhydrous magnesium sulphate and evaporated to dryness. The resulting oil was purified by column chromatography to give N-methyl-N-propyloctylamine as a colourless oil (4.09 g, 63%).

1. temperaturecooled to 5°
2. temperaturemaintaining the temperature below 20°
3. customat 20°
4. temperaturecooled
5. extractionThe aqueous solution was extracted with dichloromethane (2×75 ml)
6. dry with materialThe combined extracts were dried with anhydrous magnesium sulphate
7. customevaporated to dryness
8. customThe resulting oil was purified by column chromatography