HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Methyl 6-chloropyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Product | Methyl 6-chloropyridine-3-carboxylate | HCID 254249 | — |
Reaction Steps
An ethereal solution of CH2N2 (0.1 mole) is added to a suspension of 6-chloro nicotinic acid (15 g) in CH2Cl2 until bubbling ceases. The reaction mixture is stirred overnight, evaporated and dried in vacuo affording the desired product as a tan solid used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954494 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-070433eb736945dcad9043ecb5170cd9 |
| Source note | uspto-grants-1990_09 |