HuagongsheHuagongshe Chemistry Print Report · For research reference only
[6-(1H-Imidazol-1-yl)pyridin-3-yl]methanol → 6-(1H-iMidazol-1-yl)nicotinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [6-(1H-Imidazol-1-yl)pyridin-3-yl]methanol | HCID 14207630 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-(1H-iMidazol-1-yl)nicotinaldehyde | HCID 14031650 | — |
Reaction Steps
MnO2 (18.17 g) is added to a solution of the hydroxy methyl compound of Step 3. above (6.1 g) in CHCl3, and the resulting reaction mixture heated to reflux for 22 hours, allowed to cool, filtered, and the organic layer evaporated affording the desired product as a white solid used in the next step without further purification. M.P.=139.5°-140.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954494 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-ec499654870d41699ff01b4c1ff1ecb1 |
| Source note | uspto-grants-1990_09 |