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HRID1031428

反应详情

EQUATION

反应方程式

HRID 1031428 的结构方程式

REACTANTS

反应物

2
结构：N
HCID222

Ammonia gas

H3N

结构：CC1CC(=O)NN=C1c1ccc(Cl)c([N+](=O)[O-])c1
HCID2874432

6-(4-chloro-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

C11H10ClN3O3

PRODUCTS

生成物

1
结构：CC1CC(=O)NN=C1c1ccc(N)c([N+](=O)[O-])c1
HCID3111187

6-(4-Amino-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

C11H12N4O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 5 g of 6-(4-chloro-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one, 50 ml of 25% aqueous NH3 solution and 50 ml of ethanol is heated at 100° for 16 hours. The mixture is poured into ice water and extracted with methylene dichloride, the phases are separated and the organic phase is dried over sodium sulfate and evaporated to give 6-(4-amino-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 234°-238°.

WORKUP

后处理

  1. temperatureis heated at 100° for 16 hours
  2. extractionextracted with methylene dichloride
  3. customthe phases are separated
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. customevaporated