HCID 19896765, compound → HCID 19896763, compound

HRID 1031452Notes

Reaction equation

HRID 1031452 reaction equation
[CH3:1][C:2]1([CH3:31])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[CH:17][C:16]=4[O:26][CH2:27][CH:28]=[CH2:29])=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:30])[CH2:3]1>C(O)C.[Pd]>[CH3:31][C:2]1([CH3:1])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[CH:17][C:16]=4[O:26][CH2:27][CH2:28][CH3:29])=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:30])[CH2:3]1

Participants

4

Reactant 1

HCID 19896765HCID 19896765, compound

Product 1

HCID 19896763HCID 19896763, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2 g. 8,8-Dimethyl-2-(4-diethylamino-2-allyloxy-phenyl)-5,6,7,8-tetrahydro-lH-imidazo[4,5-g]quinolin-6-one were hydrogenated in ethanol in the presence of palladium/charcoal. After completion of the take up of hydrogen, the catalyst was filtered off, the filtration was evaporated and the residue recrystallised from isopropanol to give 1.8 g. of the title compound; m.p. 147 -148° C.

Workup

  1. filtrationAfter completion of the take up of hydrogen, the catalyst was filtered off
  2. filtrationthe filtration
  3. customwas evaporated
  4. customthe residue recrystallised from isopropanol
  5. customto give 1.8 g

Sources & evidence

ORD record
ord-c4f6b6440eda4204bd1171e8050cd6e8
Source dataset
uspto-grants-1990_09
Patent number
US04954498

Reaction notes

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