Pyridine → 6-[4-(4-ethoxycarbonyl-piperidin-1-yl)-3-nitro-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

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Reaction Steps

2.68 g (10 mmol) of 6-(4-chloro-3-nitro-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone are boiled under reflux with 3.14 g (20 mmol) of piperidine-4-carboxylic acid ethyl ester and 0.81 ml (10 mmol) of pyridine in 50 ml of dioxane for 5 hours. The reaction mixture is then poured out on 200 ml of ice water and suction filtered to separate the solid, and the filter cake is then washed with water.

Provenance & Evidence