HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-[4-(5-Methyl-3-oxo-2,3,4,5-tetrahydro-6-pyridazinyl)-2-nitro-phenyl]-piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-[4-(4-ethoxycarbonyl-piperidin-1-yl)-3-nitro-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone | HCID 14459470 | — |
| Solvent | 1-Methoxyethanol | HCID 3015637 | — |
| Product | 1-[4-(5-Methyl-3-oxo-2,3,4,5-tetrahydro-6-pyridazinyl)-2-nitro-phenyl]-piperidine-4-carboxylic acid | HCID 14459486 | — |
Reaction Steps
1.2 g (3.1 mmol) of 1-[2-nitro-4-(5-methyl-3-oxo-2,3,4,5-tetrahydro-6-pyridazinyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester are heated under reflux in a solution of 0.4 g (9.3 mmol) of sodium hydroxide in 40 ml of methoxyethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954501 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-44b4c080b2cf4602bd97c9e4b0569a36 |
| Source note | uspto-grants-1990_09 |