HCID 14459483, compound → HCID 14459488, compound

Participants

Reaction Steps

3.0 g (10.3 mmol) of 6-[4-(2-aminoethyl)amino-3-nitro-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone in 200 ml of methanol are hydrogenated under a hydrogen pressure of 2 bar at room temperature in the presence of 0.5 g of palladium charcoal (10% Pd) until uptake of hydrogen ceases. After removal of the catalyst by filtration, the solution is concentrated by evaporation under vacuum. The residue is chromatographed on silica gel with methanol/conc. ammonia (95/5) as solvent. The main fraction is concentrated by evaporation under vacuum and the solid obtained is recrystallized from ethanol. 1.37 g (51%) of a beige coloured solid, m.p. 176°-177° C. are obtained.

Provenance & Evidence