Ethyl chloroformate → HCID 14459503, compound

Participants

Reaction Conditions

Reaction Steps

1.2 g (8.6 mmol) of potassium carbonate are added to a solution of 1.0 g (3.4 mmol) of 6-[3-fluoro-4-(piperazin-1-yl)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone in 10 ml of acetone and 10 ml of water. When the suspension has cooled down to 0° C., 0.42 ml (4.4 mmol) of ethyl chloroformate are added and stirring is continued for 30 minutes. The precipitated solid is suction filtered, washed with 10 ml of acetone-water mixture and recrystallized from 40 ml of acetonitrile. 0.73 g (60%) of a colourless solid, m.p. 193°-194° C., are obtained.

Provenance & Evidence