Potassium Carbonate → HCID 9819146, compound

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A mixture of 3-(2-bromoethyl)indole (2.00 g), 1-(3-methoxy-2-pyridinyl)piperazine (1.72 g), micropulverized K2CO3 (2.46 g) and tetrabutylammonium hydrogen sulfate (0.15 g), in acetonitrile (50 mL) was heated at reflux under N2 atmosphere for 5 h. The excess acetonitrile was removed under reduced pressure and water (10 mL) was added to the concentrate. The aqueous phase was extracted with CH2Cl2 (3×50 mL). The combined CH2Cl2 extracts were washed with sat. NaCl solution, dried with anhydrous K2CO3, and concentrated under reduced pressure. Silica gel chromatography (CH2Cl2 /MeOH; 96.4) of the residue yielded the free base of the desired Ia product (1.32 g; 44%).

Provenance & Evidence