1,3-Dimethyl-1H-pyrazol-5-amine → HCID 136404512, compound

HRID 1031522Notes

Reaction equation

HRID 1031522 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4](=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])[C:5]([CH3:7])=O.[CH3:19][N:20]1[C:24]([NH2:25])=[CH:23][C:22]([CH3:26])=[N:21]1>C(O)C>[CH3:1][O:2][C:3]([C:4]1[CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[C:23]2[C:22]([CH3:26])=[N:21][N:20]([CH3:19])[C:24]=2[NH:25][C:5]=1[CH3:7])=[O:18]

Participants

4

Reactant 2

HCID 5207211,3-Dimethyl-1H-pyrazol-5-amineHCID 787115Methyl 2-(2-nitrobenzylidene)acetoacetate

Product 1

HCID 136404512HCID 136404512, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl-2-(2-nitrobenzyliden)acetoacetate (10 g; 0.040 mol) is added to 1,3-dimethyl-5-pyrazolamine (4.89 g; 0.044 mol) in ethanol (40 ml) The mixture is refluxed for about 5 hours, then the solvent is evaporated under reduced pressure and the residue is taken up in ethyl ether and recovered by filtration. M.p. 216°-220° C.

Workup

  1. temperatureis refluxed for about 5 hours
  2. customthe solvent is evaporated under reduced pressure
  3. filtrationrecovered by filtration

Sources & evidence

ORD record
ord-ab28f9f8203f4d75819fff3d6c394ac0
Source dataset
uspto-grants-1990_09
Patent number
US04954508

Reaction notes

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