Sodium Hydroxide → HCID 488653, compound

HRID 1031556Notes

Reaction equation

HRID 1031556 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[C:10]([F:24])[C:11]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:7]=1)=[O:5])C.[OH-].[Na+]>>[N:18]1([C:11]2[C:10]([F:24])=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:13][C:12]=2[F:17])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 14839598HCID 14839598, compound

Product 1

HCID 488653HCID 488653, compoundYield 78.5%

Procedure

0.805 g (2,04 mmoles) of 7-piperazinyl-1-(1,1 dimethylethyl)-1,4-dihydro-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester was hydrolyzed with 1,05 mL 2N NaOH for two hours. The solution was evaporated to dryness neutralized with 5% acetic acid (pH 7.0). The solid was filtered to give 0.585 g of titled compound.

Workup

  1. customThe solution was evaporated to dryness
  2. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-90b136fdfae14c44ac7898aa7148b04c
Source dataset
uspto-grants-1990_09
Patent number
US04954507

Reaction notes

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