HCID 14839577, compound → 1-(3,8-Diazabicyclo[3.2.1]oct-8-yl)-2,2,2-trifluoroethanone

HRID 1031565Notes

Reaction equation

HRID 1031565 reaction equation
Cl.C([N:9]1[CH2:15][CH:14]2[N:16]([C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[CH:11]([CH2:12][CH2:13]2)[CH2:10]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:21][C:18]([F:19])([F:20])[C:17]([N:16]1[CH:11]2[CH2:12][CH2:13][CH:14]1[CH2:15][NH:9][CH2:10]2)=[O:22]

Participants

5

Reactant 2

HCID 14839577HCID 14839577, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 148395781-(3,8-Diazabicyclo[3.2.1]oct-8-yl)-2,2,2-trifluoroethanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of the 3-benzyl-8-trifluoroacetyl-3,8-diazabicyclo-(3.2.1)octane hydrochloride in 50 mL of methanol was hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.5 g) until the theoretical quantity of hydrogen was absorbed. The mixture was filtered and the filtrate was evaporated to dryness to yield 1.08 g of titled compound as a white solid. MP 224° C. (dec).

Workup

  1. customwas absorbed
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-b36aed7965b6483aa48b60deb0c05357
Source dataset
uspto-grants-1990_09
Patent number
US04954507

Reaction notes

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