Acetic Acid → HCID 22168042, compound

HRID 1031604Notes

Reaction equation

HRID 1031604 reaction equation
[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]2C(OCC2C=CC=CC=2)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29][C:30]([OH:32])=[O:31]>[Pd]>[C:30]([OH:32])(=[O:31])[CH3:29].[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 15005485HCID 15005485, compound

Product 1

HCID 22168042HCID 22168042, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

0.840 g (2.21 mmoles) of (+)-1-(pyrrolidin-1-yl)methyl-2-benzyloxycarbonyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline were hydrogenated in 90% CH3COOH at 30 psi, 3 hours, at room temperature over 100 mg of 5% Palladium on activated charcoal.

Sources & evidence

ORD record
ord-d0247489c84041329f3643e4f515f99f
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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