HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 1-(pyrrolidin-1-Yl)methyl-2-(3,4-dichlorophenyl)acetyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3,4-Dichlorophenylacetic acid | HCID 79874 | — |
| Reactant | HCID 15005443 | HCID 15005443 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(pyrrolidin-1-Yl)methyl-2-(3,4-dichlorophenyl)acetyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline | HCID 22168044 | — |
Reaction Steps
Prepared as Ex. No. 1, from 1.2 g (4.88 mmoles) of 1-(pyrrolidin-1-yl)methyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline, 1.1 g (5.37 mmoles) of 3,4-dichlorophenylacetic acid and 2.2 g (10.68 mmoles) of dicyclohexylcarbodiimide in 50 ml of dry methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954509 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-28420926808140fdab1b918873292405 |
| Source note | uspto-grants-1990_09 |