Dicyclohexylcarbodiimide → HCID 22168000, compound

Participants

Reaction Steps

Prepared as Ex. No. 1, from 4.3 g (17.48 mmoles) of a mixture containing 1-(pyrrolidin-1-yl)methyl-8-methoxy-1,2,3,4-tetrahydroisoquinoline and 1-(pyrrolidin-1-yl)methyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline, 4.3 g (20.98 mmoles) of 3,4-dichlorophenylacetic acid, and 8.0 g (38.80 mmoles) of dicyclohexylcarbodiimide, in 110 ml of dry methylene chloride. The silica gel chromatographic column was eluted with CH2Cl2, containing increasing amounts of MeOH (0.6-2.5%); 1.5 g of the crude product were obtained and dissolved in 40 ml of ethyl acetate. The solution was brought to acidic pH with HCl/diethyl ehter and the precipitate filtered, washed and dried, to yield 1.2 g of the title compound.

Provenance & Evidence