2-(3,4-Dichlorophenyl)acetyl chloride → HCID 22168093, compound

HRID 1031616Notes

Reaction equation

HRID 1031616 reaction equation
[N:1]1([CH2:7][CH:8]2[C:17]3[C:12](=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](Cl)=[O:30])[CH:24]=[CH:25][C:26]=1[Cl:27]>C(Cl)(Cl)Cl>[ClH:20].[N:1]1([CH2:7][C:8]2([C:29](=[O:30])[CH2:28][C:23]3[CH:24]=[CH:25][C:26]([Cl:27])=[C:21]([Cl:20])[CH:22]=3)[C:17]3[C:12](=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 22168063HCID 22168063, compound

Product 1

HCID 22168093HCID 22168093, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. No. 33, from 600 mg (2.31 mmoles) of 1-(piperidin-1-yl)methyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline and 630 mg (2.82 mmoles) of 3,4-dichlorophenyl acetyl chloride in 20 ml of dry chloroform.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-37a09e9473b940769e342c95e5bb4a66
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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