HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(Piperidin-1-yl)methyl-2-(3,4-dichlorophenyl)acetyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(3,4-Dichlorophenyl)acetyl chloride | HCID 2758149 | — |
| Reactant | HCID 22168109 | HCID 22168109 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-(Piperidin-1-yl)methyl-2-(3,4-dichlorophenyl)acetyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 22168066 | — |
Reaction Steps
Prepared as Ex. No. 34, from 1.65 g (4.06 mmoles) of 1-(piperidin-1-yl)methyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline dihydrobromide, 2.6 ml (18.50 mmoles) of Et3N and 2.2 g (9.84 mmoles) of 3,4-dichlorophenyl acetyl chloride in 50 ml of dry chloroform.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954509 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-4f03c6f6c6d34f75a47a869caecbfcb7 |
| Source note | uspto-grants-1990_09 |