2-Thiophenecarbonyl chloride → HCID 22168102, compound

HRID 1031620Notes

Reaction equation

HRID 1031620 reaction equation
[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([OH:17])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>C(Cl)(Cl)Cl>[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([OH:17])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]2[C:23]([C:19]2[S:18][CH:22]=[CH:21][CH:20]=2)=[O:24])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 15005457HCID 15005457, compound

Product 1

HCID 22168102HCID 22168102, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. N° 55, from 0.88 g (3.78 mmoles) of 1-(pyrrolidin-1-yl) methyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline and 0.83 g (5.66 mmoles) of 2-thiophene carbonyl chloride in 60 ml of dry chloroform, at -10° C.

Workup

  1. customPrepared as Ex
  2. customat -10° C.

Sources & evidence

ORD record
ord-d409d75992dd42d1a8e7c15bc1702a9d
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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