Phenol, 4-methoxy-2-nitro- → 2-Amino-4-methoxyphenol

Participants

Reaction Steps

20 g of 4-methoxy-2-nitrophenol was suspended in 350 ml of ethanol. Thereto was added 550 mg of 5% palladium-carbon. The mixture was subjected to hydrogenation at 20°-30° C. at atmospheric pressure. After the completion of the reaction, the catalyst was removed by filtration and then the solvent was removed by distillation under reduced pressure. The resulting crystal was recrystallized from isopropyl alcohol to obtain 15.3 g (yield: 93%) of 2-amino-4-methoxyphenol.

Provenance & Evidence