Aluminum(III) Chloride → HCID 10734538, compound

Participants

Reaction Steps

10.0 g of methyl 4-methylsulfonylamino-2-methoxy-5-phenoxyphenyl ketone was dissolved in 100 ml of methylene chloride. 3.98 g of aluminum chloride was added thereto in portions in 30 minutes with ice-cooling. The mixture was stirred for 1 hour at 20°-25° C. The reaction mixture was introduced into 100 ml of ice water. The organic layer was separated, washed with water and a saturated aqueous sodium chloride solution in this order, and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The resulting crystal was recrystallized from isopropyl alcohol to obtain 8.8 g (yield: 91.9%) of methyl 2-hydroxy-4-methylsulfonylamino-5-phenoxyphenyl ketone having a melting point of 151-153° C.

Provenance & Evidence