Hydrochloric Acid → HCID 22168214, compound

Participants

Reaction Steps

24 ml of a 1N aqueous sodium hydroxide solution was added to 1.2 g of methyl trans-3-[4-(2,4-difluorophenoxy)-3-methylsulfonylaminophenoxy]acrylate. The mixture was stirred for 1 hour at 20°-25° C. 30 ml of ethyl acetate was added thereto. The resulting mixture was adjusted to pH 4 with 4N hydrochloric acid. The organic layer was separated, washed with water and a saturated aqueous sodium chloride solution in this order, and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to obtain 1.0 g (yield: 87.0%) of oily trans-3-[4-(2,4-difluorophenoxy)-3methylsulfonylaminophenoxy]acrylic acid.

Provenance & Evidence