Water → 3-formyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one

Participants

Reaction Steps

25 g of 2-(2-hydroxy-4-methylsulfonylamino-5-phenoxybenzoyl)acetaldehyde was dissolved in 260 ml of benzene and 130 ml of N,N-dimethylformamide. Thereto was added 26 ml of N,N-dimethylformamide dimethylacetal. The mixture was stirred for 8 hours at room temperature. The reaction mixture was introduced into a mixture consisting of 200 ml of ethyl acetate and 200 ml of water. The organic layer was separated, washed with water and a saturated aqueous sodium chloride solution in this order, and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The resulting oily matter was purified by a column chromatography (eluant: a 20 : 1 mixture of toluene and ethyl acetate) to obtain 13 g (yield: 50.4%) of 3-formyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one.

Provenance & Evidence