HCID 10808954, compound → HCID 10761590, compound

Participants

Reaction Steps

3.67 g of 6-(2,4-difluorophenoxy)-7-methylsulfonylamino-4H-1-benzopyran-4-one was suspended in 60 ml of acetic acid. Thereto was added 400 mg of 5% palladium-carbon. The mixture was subjected to hydrogenation at 40°-50° C. at atmospheric pressure. After the completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated. The resulting crystal was recrystallized from ethanol to obtain 3.16 g (yield: 85.6%) of 6-(2,4-difluorophenoxy)-2,3-dihydro-7-methylsulfonylamino-4H-1-benzopyran-4-one having a melting point of 163.5°-165° C.

Provenance & Evidence