Formic Acid → HCID 14722379, compound

Participants

Reaction Steps

340 mg of acetic anhydride and 310 mg of formic acid were mixed. The mixture was stirred for 1.5 hours at 40°-45° C. Thereto was added 10 ml of methylene chloride. There was further added 400 mg of 7-methylsulfonylamino-3-methylamino-6-phenoxy-4H-1-benzopyran-4-one. The resulting mixture was stirred for 1 hour at 25°-30° C. 10 ml of diisopropyl ether was added thereto. The resulting crystal was collected by filtration and then recrystallized from acetonitrile to obtain 330 mg (yield: 76.7%) of 7-methylsulfonylamino-3-(N-formyl-N-methylamino)-6-phenoxy-4H-1-benzopyran-4-one.

Provenance & Evidence