1,4-Dioxane hydrochloride → HCID 178485749, compound

HRID 1031749Notes

Reaction equation

HRID 1031749 reaction equation
[CH3:1][NH:2][C:3](=[O:30])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH:5][C:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH:15]C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)=[O:7].[ClH:31].O1CCOCC1>>[ClH:31].[CH3:1][NH:2][C:3](=[O:30])[C@H:4]([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[NH:5][C:6]([C@H:8]1[CH2:9][CH2:10][C@H:11]([CH2:14][NH2:15])[CH2:12][CH2:13]1)=[O:7]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178485750HCID 178485750, compound

Product 1

HCID 178485749HCID 178485749, compound

Procedure

To the compound (III) (2.29 g) was added 4N hydrogen chloride/1,4-dioxane solution (23 ml), and the mixture was stirred at room temperature for one hour. The solvent was evaporated under a reduced pressure, and the residue was washed with ethyl ether and filtered to give N-(trans-4-aminomethylcyclohexylcarbonyl)-L-phenylalanine methylamide hydrochloride (2.03 g) as a white powder.

Workup

  1. customThe solvent was evaporated under a reduced pressure
  2. washthe residue was washed with ethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-29726732cd3d4bfaa61b62bb8c531638
Source dataset
uspto-grants-1990_09
Patent number
US04954512

Reaction notes

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