1,4-Dioxane hydrochloride → HCID 178484586, compound

HRID 1031752Notes

Reaction equation

HRID 1031752 reaction equation
[CH3:1][NH:2][C:3](=[O:30])[C@H:4]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH:5][C:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH:15]C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)=[O:7].[ClH:31].O1CCOC[CH2:33]1>>[ClH:31].[CH3:1][N:2]([CH3:33])[C:3](=[O:30])[C@H:4]([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[NH:5][C:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH2:15])[CH2:10][CH2:9]1)=[O:7]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178485750HCID 178485750, compound

Product 1

HCID 178484586HCID 178484586, compound

Procedure

To the compound (III) (34.30 g) was added 4N hydrogen chloride/1,4-dioxane solution (400 ml) under room temperature, and the mixture was stirred for 30 minutes. The mixture was concentrated under a reduced pressure, and the residue was washed with diethyl ether, followed by filtration to give N-(trans-4-aminomethyl-cyclohexylcarbonyl)-L-phenylalanine dimethylamide hydrochloride (28.50 g).

Workup

  1. concentrationThe mixture was concentrated under a reduced pressure
  2. washthe residue was washed with diethyl ether
  3. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-b51e69f8521b4bcc95410d0e212427d9
Source dataset
uspto-grants-1990_09
Patent number
US04954512

Reaction notes

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