反应详情

To the compound (III) (34.30 g) was added 4N hydrogen chloride/1,4-dioxane solution (400 ml) under room temperature, and the mixture was stirred for 30 minutes. The mixture was concentrated under a reduced pressure, and the residue was washed with diethyl ether, followed by filtration to give N-(trans-4-aminomethyl-cyclohexylcarbonyl)-L-phenylalanine dimethylamide hydrochloride (28.50 g).

1. concentrationThe mixture was concentrated under a reduced pressure
2. washthe residue was washed with diethyl ether
3. filtrationfollowed by filtration