Diethyl Ether → HCID 18631455, compound

HRID 1031802Notes

Reaction equation

HRID 1031802 reaction equation
C([O:5][C:6](=[O:39])[CH2:7][N:8]([C:18](=[O:38])[C@H:19]([CH3:37])[NH:20][C@H:21]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)(C)(C)C.[BrH:40].C(O)(=O)C.C(OCC)C>C(O)(=O)C>[BrH:40].[BrH:40].[CH2:35]([O:34][C:32]([C@@H:21]([NH:20][C@H:19]([C:18]([N:8]([CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)[CH2:7][C:6]([OH:39])=[O:5])=[O:38])[CH3:37])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1)=[O:33])[CH3:36]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 54310579HCID 54310579, compound

Product 1

HCID 18631455HCID 18631455, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In 2 ml of acetic acid is dissolved 0.3 g of N-[N-[(S)-5-(4-piperidyl)-1-ethoxycarbonylpentyl]-L-alanyl]-N-(indan-2-yl)glycine tert-butyl ester, and 1 ml of hydrogen bromide-acetic acid solution is added to the solution, followed by standing at room temperature for 30 minutes. 50 ml of ethyl ether is added to the reaction solution, followed by shaking, and the supernatant layer is removed by decantation. The precipitate is collected and dried under reduced pressure to give 0.3 g of N-[N-[(S)-1-ethoxycarbonyl-5-(4-piperidyl)pentyl]-L-alanyl]-N-(indan-2-yl)glycine.dihydrobromide as a colorless powder.

Workup

  1. additionis added to the solution
  2. customthe supernatant layer is removed by decantation
  3. customThe precipitate is collected
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-ce9865d7fdf942a7a2d6e54e8c10e98d
Source dataset
uspto-grants-1990_09
Patent number
US04954625

Reaction notes

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