HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → (S)-Metoprolol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | ((p-(2-Methoxyethyl)phenoxy)methyl)oxirane | HCID 92515 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-Metoprolol | HCID 157716 | — |
Reaction Steps
214 mg of (+)-4-(2-methoxyethyl)-phenyl glycidyl ether were condensed with isopropylamine as in Example 2 to obtain 146 mg of (-)-metoprolol melting at 44-46° C. with [α]D25=- 5.00° (c=1.01 in ethanol). Optical purity (method as in Example 2) was determined to be 98%. Evaporation of the mother liquor yielded 9 mg of (-)-metoprolol of 97.5% optical purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04956284 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-f9d1bdfab3334f2ebf43e6e8dfbb7904 |
| Source note | uspto-grants-1990_09 |