Sodium Hydroxide → [4-(Morpholin-4-yl)pyrimidin-2-yl]methanol

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Reaction Steps

A solution of 24 ml of boron tribromide in 100 ml of dichloromethane was added dropwise, at -25° C. under a nitrogen atmosphere, to a solution of 13 g of 2-methoxymethyl-4-morpholinopyrimidine in 100 ml of dichloromethane. After 30 minutes at -25° C., the solution was left to stand at 0° C. for a further 2 hours and then poured onto ice. The solution was made alkaline with sodium hydroxide solution and was extracted with dichloromethane. After drying (Na2SO4) and concentration, diethyl ether was added, and 5.5 g of 2-hydroxymethyl-4-morpholinopyrimidine were obtained as a solid (melting point 76°-77° C.).

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