Thionyl Chloride → HCID 22166995, compound

HRID 1031882Notes

Reaction equation

HRID 1031882 reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:10]=[CH:9][N:8]=1>ClCCl>[ClH:3].[Cl:3][CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:10]=[CH:9][N:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 22166960HCID 22166960, compound

Product 1

HCID 22166995HCID 22166995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 36 ml of thionyl chloride in 30 ml of dichloromethane was added dropwise, at 0° C., to a solution of 3 g of 4-hydroxymethyl-6-morpholinopyrimidine in 30 ml of dichloromethane. The reaction solution was allowed to reach room temperature and was concentrated in vacuo. Addition of diethyl ether resulted in precipitation of 3.2 g of 4-chloromethyl-6-morpholinopyrimidine hydrochloride (melting point 139° C. [decomposition]).

Workup

  1. customto reach room temperature
  2. concentrationwas concentrated in vacuo
  3. additionAddition of diethyl ether

Sources & evidence

ORD record
ord-cfef2a657bdd44bc8f1b503de7ac7c63
Source dataset
uspto-grants-1990_09
Patent number
US04956366

Reaction notes

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