HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 15068026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole | HCID 2772144 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 22167009 | HCID 22167009 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 15068026 | HCID 15068026 | 52% |
Reaction Steps
8-(4-Bromobutyl)-7,9-dioxo-8-azaspiro[4.5]decan-2-yl decanoate (3.03 g, 1.00 equiv), BITP 14 (2.38 g, 1.69 equiv) and K2CO3 (3.37 g, 3.80 equiv) were reacted in 125 mL of CH3CN according to the general procedure. Flash chromatography with a 3% to 5% MeOH/CH2Cl2 gradient yielded 12 (2.02 g, 52%) as a yellow oil. Conversion to the oxalate salt and recrystallization from CH3CN/EtOH afforded the analytically pure test compound, m.p. 117-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04956368 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-26a0de72ab654c65a92db8dfd391e337 |
| Source note | uspto-grants-1990_09 |