HCID 178418361, compound → HCID 178516243, compound

HRID 1031952Notes

Reaction equation

HRID 1031952 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:17]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]2[CH2:20][CH2:19][N:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[N:17]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178420399HCID 178420399, compound

Product 1

HCID 178516243HCID 178516243, compoundYield 65.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of N-(4-benzyloxyphenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-amine (6.9 g) in ethanol (350 ml) was hydrogenated at atmospheric pressure over 10% palladium on carbon until hydrogen uptake ceased. The mixture was filtered and the filtrate evaporated to small volume. The resulting precipitate was collected, washed with ethanol and dried to give the title compound, (3.32 g) mp 211°-14° (dec).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to small volume
  3. customThe resulting precipitate was collected
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-d9e2cdf0406a4225b684924f2a919c54
Source dataset
uspto-grants-1990_09
Patent number
US04956378

Reaction notes

Loading…