HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 14422918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester | HCID 535415 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 14422918 | HCID 14422918 | — |
Reaction Steps
2.7 g of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate and 1.1 g of malononitrile are initially introduced into 30 ml of dioxane. 1.91 g of potassium tert-butoxide are added in portions. The mixture is warmed to 50° for 4 hours, cooled to room temperature, and acidified using HCl, and the red solid is isolated. It is recrystallized from glycol monomethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04956465 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-73181e37d418458b850515f61c9c48f1 |
| Source note | uspto-grants-1990_09 |