Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl cyanoacetate → Ethyl 7-(cyano-ethoxycarbonyl-methyl)-6,8-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Ethyl 1-(4-fluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylate | HCID 13728329 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 7-(cyano-ethoxycarbonyl-methyl)-6,8-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylate | HCID 14422917 | — |
반응 단계
0.12 g of sodium hydride are initially introduced into 15 ml of dioxane. 0.51 g of ethyl cyanoacetate is added and the mixture is first stirred for one hour at room temperature. 1.1 g of ethyl 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylate are then added in portions. The mixture is boiled for 3 hours, diluted using water and acidified. It is extracted using methylene chloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04956465 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-35cf28b0dbc44a8bbdb3f60fe08ab392 |
| 출처 메모 | uspto-grants-1990_09 |