Thionyl Chloride → 7-Amino-4-methylcoumarin-3-acetic chloride

Participants

Reaction Steps

The reaction was carried out in a 500 ml two-necked reaction flask, containing 50 ml toluene, 7-amino-4-methylcoumarin-3-acetic acid (prepared as per Example 1 above), 699 mg (3 mmol) and thionyl chloride, 0.278 ml (446 ng, 3.75 mmol, BDH Chemicals, U.K.). Nitrogen was passed through the mixture during the reaction. The mixture was refluxed for 2 hours on an oil bath (temperature 130°-150° C.). The solvent was removed by rotatory evaporation and the precipitate was dried in vacuo.

Provenance & Evidence