HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl p-chlorobenzalpyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(4-Chlorophenyl)-2-oxobut-3-enoic acid | HCID 367457 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl p-chlorobenzalpyruvate | HCID 54351366 | 99% |
Reaction Steps
To the p-chlorobenzalpyruvic acid from step A in wet ethyl acetate was added triethylamine (11.1 g, 0.11 moL) at a rate less than 0.5 mL/min followed by azeotropic removal of water. Ethyl chloroformate (11.9 g, 0.11 moL) was then added at room temperature over a one hour period and the batch aged one hour to effect complete reaction. Workup followed, as in Example 1, to afford ethyl p-chlorobenzalpyruvate in 99% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04956490 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-175cd20443e9451c9c4ef28cd610ad24 |
| Source note | uspto-grants-1990_09 |