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Fumaric Acid → 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Fumaric Acid | HCID 444972 | — |
| 反応物 | 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine | HCID 15053405 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate | HCID 19799593 | 91.3% |
反応手順
A 2.5 g portion of 1-[3-(4-fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine was dissolved in isopropanol and treated with 0.8 g of fumaric acid dissolved in 2.5 ml of hot isopropanol. Upon cooling, the precipitate was collected by filtration, yielding 3 g (91.3%) of fine white crystals, m.p. 183°-184° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04956359 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-5b7ff3f8c80042018d16a6293997fd92 |
| 出典メモ | uspto-grants-1990_09 |