Sodium hydrosulfide → HCID 178494658, compound

HRID 1032207Notes

Reaction equation

HRID 1032207 reaction equation
[SH-:1].[Na+].Cl[C:4]1[N:9]2[N:10]=[C:11]([CH2:13][O:14][CH3:15])[N:12]=[C:8]2[N:7]=[C:6]([CH3:16])[CH:5]=1>O>[SH:1][C:4]1[N:9]2[N:10]=[C:11]([CH2:13][O:14][CH3:15])[N:12]=[C:8]2[N:7]=[C:6]([CH3:16])[CH:5]=1

Participants

4

Reactant 2

HCID 28015Sodium hydrosulfideHCID 15672756HCID 15672756, compound

Product 1

HCID 178494658HCID 178494658, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
55 °C

Procedure

In 350 ml of water was dissolved 24 g of sodium hydrosulfide and 34.5 g of 7-chloro-2-methoxymethyl-5-methyl-s-triazolo[1,5-a]pyrimidine was added thereto, and the mixture was stirred at 55° C. for one hour. After the reaction mixture was filtered, it was ice-cooled and adjusted to pH 1 with addition of a 2N-hydrochloric acid. The precipitates were collected by filtration, washed with water and with isopropanol, and dried to obtain 30.18 g of the title compound.

Workup

  1. additionwas added
  2. filtrationAfter the reaction mixture was filtered
  3. temperaturecooled
  4. additionadjusted to pH 1 with addition of a 2N-hydrochloric acid
  5. filtrationThe precipitates were collected by filtration
  6. washwashed with water and with isopropanol
  7. customdried

Sources & evidence

ORD record
ord-4b102b6d4e4f45fc9fde05462b2bd9e4
Source dataset
uspto-grants-1990_09
Patent number
US04956462

Reaction notes

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